Research Guide
TB-500: A Research Guide
TB-500 is a synthetic analogue of Thymosin Beta-4, a peptide naturally present in human tissue that declines with age and injury. Research documents systemic, not just localized, recovery effects spanning muscle, connective tissue, and cardiac cells.
Sources
Goldstein et al., Ann NY Acad Sci 2012; Smart et al., J Cardiovasc Pharmacol 2007. For research use only. Not approved by the FDA. Not medical advice.
Mechanism
TB-500 sequesters G-actin monomers to regulate the actin cytoskeleton, a mechanism linked to improved cell migration and the flexibility and range-of-motion gains reported in study models. It circulates systemically and concentrates preferentially at sites of active inflammation rather than requiring local administration, distinguishing it from many other repair-focused peptides.
Reconstitution & Storage
Reconstitute the lyophilized vial with bacteriostatic water before use. The reconstitution calculator on our FAQ page converts your vial size and water volume into a concentration and draw volume.
Open the reconstitution & dosing calculator →
Referenced Research Protocols
Cardiac and muscle injury research models cited below used study-specific administration schedules. This guide is a summary of published findings, not usage guidance.