Retatrutide research vial
Weight LossMetabolic

Retatrutide

10mg

Retatrutide activates GIP, GLP-1, and glucagon receptors as a triagonist, compounding effects across appetite, glucose metabolism, and hepatic fat oxidation. Phase 2 participants lost up to 24.2% of body weight, with the highest-dose cohort still descending at week 48.

Included free with every order

Bacteriostatic reconstitution solution and sterile dosing needles are included, a $30+ value, always included. Most suppliers charge extra. We never do.

Purity

99.1%

Form

Lyophilized powder

Storage

-20°C

Includes

Solution + needles

Research use only. Not for human consumption. Need help reconstituting? Use our dosing calculator.

Research Outcomes

What The Clinical Data Shows

Based on published peer-reviewed literature. Not medical claims.

24.2%

Peak body weight reduction, a clinical record

48 wks

Study duration, with no plateau reached at endpoint

338

Participants across Phase 2 dose cohorts

Glucagon pathway. Glucagon receptor agonism accelerates hepatic fat oxidation independently of GLP-1's glucose effects, adding a third, distinct fat-loss mechanism.

No plateau observed. The highest-dose cohort showed continued weight loss through week 48 with no plateau, unlike prior single- or dual-agonist compounds.

Liver fat reduction. MRI showed liver fat content reduced by more than 80% in many participants, faster than overall body weight loss.

Strongest responders. Participants with higher baseline insulin resistance responded most, a population that typically underperforms on earlier metabolic compounds.

Research context. All findings are from peer-reviewed literature. Not FDA-approved. Sold for research purposes only. Results in research settings may vary. Not medical advice.

Read the full Retatrutide research guide →